Heart Failure

tag:blogger.com,1999:blog-28033827913212029212012-01-05T20:44:53.463-08:00Heart FailureSlashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comBlogger2631100tag:blogger.com,1999:blog-2803382791321202921.post-59198777739113458222009-09-17T21:26:00.000-07:002009-09-27T21:42:12.237-07:00Neuregulin-1{beta} Is Associated With Disease Severity and Adverse Outcomes in Chronic Heart Failure

Neuregulin-1 (NRG-1) is a paracrine factor released by microvascular endothelial cells that has cardioprotective effects in animal models of heart failure. However, circulating NRG-1 has not been studied in human heart disease. We used a novel immunoassay to test whether circulating NRG-1beta is associated with disease severity and clinical outcomes in chronic heart failure.Methods and

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-17608962418885372402009-09-16T18:00:00.000-07:002009-09-27T21:39:31.967-07:00Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension

Hypertension (HTN) is a risk factor for dementia, and animal studies suggest that centrally active angiotensin-converting enzyme (ACE) inhibitors (those that cross the blood-brain barrier) may protect against dementia beyond HTN control.METHODS:Participants in the Cardiovascular Health Study Cognition Substudy with treated HTN and no diagnosis of congestive heart failure (n = 1054; mean age, 75

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-37406291278363751102009-09-15T15:56:00.000-07:002009-09-27T21:37:05.792-07:00Endothelin-converting enzyme inhibition in the model of acute heart failure

Endothelin-1 (ET-1) has been implicated in many cardiovascular diseases, including acute heart failure (AHF) due to myocardial ischemia. Previously we described the oral endothelin-converting enzyme (ECE) inhibitor, PP36, and in this study, we investigated its cardioprotective effect in more detail, and examined the role of PP36 in the neurohormonal activation in rats that had been subjected to

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-26512115376627170962009-08-27T16:00:00.001-07:002009-08-27T23:17:38.204-07:00Hormonal therapy use for prostate cancer and mortality in men with coronary artery disease-induced congestive heart failure or myocardial infarction

Hormonal therapy (HT) when added to radiation therapy (RT) for treating unfavorable-risk prostate cancer leads to an increase in survival except possibly in men with moderate to severe comorbidity. However, it is unknown which comorbid conditions eliminate this survival benefit.OBJECTIVE:To assess whether neoadjuvant HT use affects the risk of all-cause mortality in men with prostate cancer and

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-62522890330314860242009-07-28T18:21:00.000-07:002009-07-29T02:29:37.031-07:00Use of myocardial deformation imaging

Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has been mandated to detect myocardial dysfunction because of the risk of heart failure with this treatment. Myocardial deformation imaging is a sensitive means of detecting LV dysfunction, but this technique has

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-38803032222071470832009-07-22T15:07:00.001-07:002009-07-23T06:45:09.825-07:00Ambulatory Blood Pressure and Physical Activity in Heart Failure

This observational study used repeated measures over 24 hr to investigate ambulatory blood pressure (BP) and physical activity (PA) profiles in community-based individuals with heart failure (HF).The aims were to (a) compare BP dipping and PA between two groups of HF patients with different functional statuses, and (b) determine whether the strength of the association between ambulatory BP and PA

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-16832079523552421472009-07-15T15:35:00.001-07:002009-07-15T15:35:10.152-07:00Cooperative regulation of Cav1.2 channels by intracellular Mg2+, the proximal C-terminal EF-hand, and the distal C-terminal domain.

J Gen Physiol. 2009 Jul 13; Brunet S, Scheuer T, Catterall WAL-type Ca(2+) currents conducted by Ca(v)1.2 channels initiate excitation-contraction coupling in cardiac myocytes. Intracellular Mg(2+) (Mg(i)) inhibits the ionic current of Ca(v)1.2 channels. Because Mg(i) is altered in ischemia and heart failure, its regulation of Ca(v)1.2 channels is important in understanding cardiac

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-41261606935352573412009-07-15T03:48:00.001-07:002009-07-15T03:48:54.229-07:00Cardiac involvement in churg-strauss syndrome: impact of endomyocarditis.

Medicine (Baltimore). 2009 Jul; 88(4): 236-43Neumann T, Manger B, Schmid M, Kroegel C, Hansch A, Kaiser WA, Reinhardt D, Wolf G, Hein G, Mall G, Schett G, Zwerina JCardiac disease is a major contributor to disease-related death in Churg-Strauss syndrome (CSS). We conducted the current study to determine the prevalence and clinical impact of cardiac involvement in CSS patients. We performed a

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-35652824277488651462009-07-14T15:22:00.001-07:002009-07-14T15:22:03.651-07:00'And the Beat Goes On' The cardiac conduction system: the wiring system of the heart.

Exp Physiol. 2009 Jul 10; Boyett MThe Cardiac Conduction System (CCS), consisting of the sinoatrial node, atrioventricular node and His-Purkinje system, is responsible for the initiation and coordination of the heart beat. In the last decade, our understanding of the CCS has been transformed. Immunohistochemistry used in conjunction with anatomical techniques has transformed our understanding of

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-79277469503178678762009-07-14T13:52:00.001-07:002009-07-14T13:52:39.086-07:00{beta}-adrenoceptor stimulation of alveolar fluid clearance is increased in rats with heart failure.

Am J Physiol Lung Cell Mol Physiol. 2009 Jul 10; Maron MB, Luther DJ, Pilati CF, Ohanyan V, Li T, Koshy S, Horne WI, Meszaros JG, Walro JM, Folkesson HGThe alveolar epithelium plays a critical role in resolving pulmonary edema. We thus hypothesized that its function might be upregulated in rats with heart failure, a condition that severely challenges the lungs' ability to maintain fluid balance.

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-38442216613143081922009-07-14T05:36:00.001-07:002009-07-14T05:36:35.180-07:00Extreme High Temperatures and Hospital Admissions for Respiratory and Cardiovascular Diseases.

Epidemiology. 2009 Jul 10; Lin S, Luo M, Walker RJ, Liu X, Hwang SA, Chinery RBACKGROUND:: Although the association of high temperatures with mortality is well-documented, the association with morbidity has seldom been examined. We assessed the potential impact of hot weather on hospital admissions due to cardiovascular and respiratory diseases in New York City. We also explored whether the

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-82355495257734369812009-07-14T02:39:00.001-07:002009-07-14T02:39:16.766-07:00The absence of gp130 in dopamine {beta} hydroxylase-expressing neurons leads to autonomic imbalance and increased reperfusion arrhythmias.

Am J Physiol Heart Circ Physiol. 2009 Jul 10; Parrish DC, Alston EN, Rohrer H, Hermes SM, Aicher SA, Nkadi P, Woodward WR, Stubbusch J, Gardner RT, Habecker BAInflammatory cytokines that act through gp130 are elevated in the heart after myocardial infarction and in heart failure. These cytokines are potent regulators of neurotransmitter and neuropeptide production in sympathetic neurons, but are

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-78090974668194722962009-07-13T20:45:00.001-07:002009-07-13T20:45:50.342-07:00Causes of Death and Predictors of 5-Year Mortality in Young Adults After First-Ever Ischemic Stroke. The Helsinki Young Stroke Registry.

Stroke. 2009 Jul 9; Putaala J, Curtze S, Hiltunen S, Tolppanen H, Kaste M, Tatlisumak TBACKGROUND AND PURPOSE: Data on mortality and its prognostic factors after an acute ischemic stroke in young adults are scarce and based on relatively small heterogeneous patient series. METHODS: We analyzed 5-year mortality data of all consecutive patients aged 15 to 49 with first-ever ischemic stroke treated

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-14797361353097936242009-07-13T18:09:00.001-07:002009-07-13T18:09:02.448-07:00Destination therapy with a rotary blood pump and novel power delivery.

Eur J Cardiothorac Surg. 2009 Jul 7; Westaby S, Siegenthaler M, Beyersdorf F, Masseti M, Pepper J, Khayat A, Hetzer R, Frazier OHObjective: We tested the hypothesis that a miniaturised axial flow pump with infection-resistant power delivery could improve longevity and quality of life (QOL) in advanced heart failure patients deemed unsuitable for transplantation. Methods: The study included all

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-19264033401697439902009-07-13T14:10:00.001-07:002009-07-13T14:10:13.491-07:00Outcome of mildly symptomatic or asymptomatic obstructive hypertrophic cardiomyopathy: a long-term follow-up study.

J Am Coll Cardiol. 2009 Jul 14; 54(3): 234-41Sorajja P, Nishimura RA, Gersh BJ, Dearani JA, Hodge DO, Wiste HJ, Ommen SROBJECTIVES: The purpose of this study was to characterize the prognosis of minimally symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM). BACKGROUND: Recent data have suggested that obstruction may be present in the majority of HCM patients, irrespective of

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-1570557466305153992009-07-12T18:22:00.001-07:002009-07-12T18:22:21.700-07:00Reperfusion before percutaneous coronary intervention in ST-elevation myocardial infarction patients is associated with lower N-terminal pro-brain natriuretic peptide levels during follow-up, irrespec

Eur Heart J. 2009 Jul 8; Sinnaeve PR, Ezekowitz JA, Bogaerts K, Droogne W, Jarai R, Huber K, Granger CB, Desmet WJ, Armstrong PW, Van de Werf FJ, Aims N-terminal pro-brain natriuretic peptide (NT-proBNP) levels predict outcomes in ST-elevation myocardial infarction patients treated with fibrinolysis or primary percutaneous coronary intervention (PCI). However, its role in facilitated PCI has

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-90165542639632331112009-07-11T23:29:00.001-07:002009-07-11T23:29:47.990-07:00Effects of protein A immunoadsorption in patients with advanced chronic dilated cardiomyopathy.

J Clin Apher. 2009 Jul 9; Doesch AO, Konstandin M, Celik S, Kristen A, Frankenstein L, Hardt S, Goeser S, Kaya Z, Katus HA, Dengler TJOBJECTIVES:: The objective of this study was to investigate functional effects of immunoadsorption (IA) in severely limited study patients with chronic nonfamilial dilated cardiomyopathy (DCM), and to analyze the prevalence of Troponin I (TNI) autoantibodies.

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-89157339787049342222009-07-11T15:46:00.001-07:002009-07-11T15:46:12.358-07:00Pulsations in the umbilical vein during labor are associated with increased risk of operative delivery for fetal distress.

Ultrasound Obstet Gynecol. 2009 Jul 8; Ghosh GS, Fu J, Olofsson P, Gudmundsson SOBJECTIVES: Under physiological conditions the blood flow velocity waveform in the umbilical vein (UV) has an even non-pulsating pattern. Pulsations in the UV have been described in human fetuses exposed to chronic hypoxia and heart failure. Current techniques for fetal surveillance during labor and delivery involve

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-4238410064971333972009-07-11T03:50:00.001-07:002009-07-11T03:50:14.110-07:00Risk Factors and Outcomes Associated with Isolation of Meropenem High-Level-Resistant Pseudomonas aeruginosa.

Infect Control Hosp Epidemiol. 2009 Jul 7; Eagye KJ, Kuti JL, Nicolau DPObjective. To determine risk factors and outcomes for patients with meropenem high-level-resistant Pseudomonas aeruginosa (MRPA) (minimum inhibitory concentration [Formula: see text] mug/mL). Design. Case-control-control. Setting. An 867-bed urban, teaching hospital. Patients. Fifty-eight MRPA case patients identified from

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-37498901349195566832009-07-10T23:11:00.001-07:002009-07-10T23:11:36.564-07:00Cardiovascular disease in African American women: a health care disparities issue.

J Natl Med Assoc. 2009 Jun; 101(6): 536-40Williams RAOBJECTIVES: To review the current status of cardiovascular disease (CVD) in African American women compared to Caucasian women in regards to 4 categories of CVD: coronary artery disease (CAD), hypertension, stroke, and congestive heart failure (CHF), and to call attention to the need to place more emphasis on the need to increase awareness of

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-54398034627209681012009-07-10T20:32:00.001-07:002009-07-10T20:32:28.910-07:00Endothelin receptor antagonists for pulmonary arterial hypertension.

Cochrane Database Syst Rev. 2009; CD004434Liu C, Chen J, Gao Y, Deng B, Liu KBACKGROUND: Pulmonary arterial hypertension is a devastating disease, which leads to right heart failure and premature death. Recent evidence suggests that endothelin receptor antagonists may be promising drugs in the treatment of pulmonary arterial hypertension. OBJECTIVES: To evaluate the efficacy of endothelin

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-19289141951103599502009-07-10T18:03:00.001-07:002009-07-10T18:03:11.545-07:00Mifepristone for induction of labour.

Cochrane Database Syst Rev. 2009; CD002865Hapangama D, Neilson JPBACKGROUND: The steroid hormone, progesterone, inhibits contractions of the pregnant uterus at all gestations. Antiprogestins (including mifepristone) have been developed to antagonise the action of progesterone, and have a recognised role in medical termination of early or mid-trimester pregnancy. Animal studies have suggested

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-53526950624615225412009-07-10T16:14:00.000-07:002009-07-10T16:14:00.227-07:00Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care.

Health Technol Assess. 2009 Jul; 13(32): 1-232Mant J, Doust J, Roalfe A, Barton P, Cowie M, Glasziou P, Mant D, McManus R, Holder R, Deeks J, Fletcher K, Qume M, Sohanpal S, Sanders S, Hobbs FOBJECTIVES: To assess the accuracy in diagnosing heart failure of clinical features and potential primary care investigations, and to perform a decision analysis to test the impact of plausible diagnostic

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-37288796252421827002009-07-09T20:44:00.001-07:002009-07-09T20:44:41.578-07:00The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 3--valve plus coronary artery bypass grafting surgery.

Ann Thorac Surg. 2009 Jul; 88(1 Suppl): S43-62Shahian DM, O'Brien SM, Filardo G, Ferraris VA, Haan CK, Rich JB, Normand SL, DeLong ER, Shewan CM, Dokholyan RS, Peterson ED, Edwards FH, Anderson RP, BACKGROUND: Since 1999, The Society of Thoracic Surgeons (STS) has published two risk models that can be used to adjust the results of valve surgery combined with coronary artery bypass graft surgery

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-45290032520164572952009-07-08T08:21:00.001-07:002009-07-08T08:21:48.471-07:00Two-dimensional strain as a marker of subclinical anterior ischaemia in anomaly of left coronary artery arising from pulmonary artery.

Eur J Echocardiogr. 2009 Jul; 10(5): 732-5Iriart X, Jalal Z, Derval N, Latrabe V, Thambo JBA 13-year-old boy was admitted to our department after an out-of-hospital cardiac arrest during physical exertion. Transitory ST-segment elevation in the anterior chest leads was noted after defibrillation. At 48 h, initial evaluation was performed. Twelve-lead EKG and telemetry were normal. Transthoracic

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-28760565471220576382009-07-07T21:20:00.001-07:002009-07-07T21:20:33.544-07:00Left Ventricular Mechanical Assist Devices and Cardiac Device Interactions: An Observational Case Series.

Pacing Clin Electrophysiol. 2009 Jul; 32(7): 879-87Foo D, Walker BD, Kuchar DL, Thorburn CW, Tay A, Hayward CS, Macdonald P, Keogh A, Kotlyar E, Spratt P, Jansz PBackground: Nonpulsatile left ventricular assist devices (LVADs) are increasingly used for treatment of refractory heart failure. A majority of such patients have implanted cardiac devices, namely implantable cardioverter-defibrillators

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-19849300690450860432009-07-07T18:57:00.001-07:002009-07-07T18:57:22.501-07:00In-Hospital Treatment of Obstructive Sleep Apnea During Decompensation of Heart Failure.

Chest. 2009 Jun 30; Khayat RN, Abraham WT, Patt B, Pu M, Jarjoura DBackground Treatment of obstructive sleep apnea (OSA) in outpatients with systolic heart failure improves cardiac function. We evaluated the impact of immediate inpatient diagnosis and treatment of OSA in hospitalized patients with acutely decompensated heart failure (ADHF) on in-hospital cardiac outcomes. Methods A pilot

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-82620127128704526222009-07-07T16:51:00.001-07:002009-07-07T16:51:24.768-07:00Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure.

PLoS One. 2009; 4(7): e6117Palpant NJ, Szatkowski ML, Wang W, Townsend D, Bedada FB, Koch LG, Britton SL, Metzger JMOxygen metabolism is a strong predictor of the general health and fitness of an organism. In this study, we hypothesized that a divergence in intrinsic aerobic fitness would co-segregate with susceptibility for cardiovascular dysfunction. To test this hypothesis, cardiac function

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-62206072824706974162009-07-06T23:00:00.001-07:002009-07-06T23:00:11.264-07:00The burden of chronic obstructive pulmonary disease in patients hospitalized with heart failure.

Wien Klin Wochenschr. 2009; 121(9-10): 309-13Lainscak M, Hodoscek LM, DÃ¼ngen HD, Rauchhaus M, Doehner W, Anker SD, von Haehling SOBJECTIVES: Like chronic heart failure, chronic obstructive pulmonary disease (COPD) is an enormous public health problem in industrialized countries. Our aim was to determine the prevalence and clinical impact of COPD among patients hospitalized for heart failure in

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-18653774716152548802009-07-06T01:41:00.001-07:002009-07-06T01:41:02.653-07:00[Critical care and therapy based different illness state of 80 patients with severe hand-foot-and-mouth disease seen in Shenzhen.]

Zhonghua Er Ke Za Zhi. 2009 May; 47(5): 338-343He YX, Fu D, Cao DZ, Liu HY, Huang QL, Li CROBJECTIVE: To discuss the treatment strategy of severe hand-foot-and-mouth disease (HFMD) cases, prevent the severe cases from progressing to fatal condition and enhance the survival rate of critically ill patients. METHODS: Eighty HFMD cases were divided into four groups, A, B, C and D, according to the

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-55954740294950412702009-07-05T22:31:00.001-07:002009-07-05T22:31:09.283-07:00Left Ventricular Ejection Fraction as Criterion for Implantation of an Implantable Cardioverter-Defibrillator in Heart Failure Patients Undergoing Surgical Left Ventricular Reconstruction.

Pacing Clin Electrophysiol. 2009 Jul; 32(7): 913-917Mollema SA, Klein P, Heersche J, Schalij MJ, VAN DER Wall EE, Versteegh MI, Klautz RJ, VAN Erven L, Bax JJBackground: Besides implantation of an implantable cardioverter-defibrillator (ICD), a proportion of patients with left ventricular (LV) dysfunction due to ischemic cardiomyopathy are potential candidates for surgical LV reconstruction (Dor

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-86596708364596064382009-07-05T19:01:00.001-07:002009-07-05T19:01:44.127-07:00An exploration of how guideline developer capacity and guideline actionability influence implementation and adoption: study protocol.

Implement Sci. 2009 Jul 2; 4(1): 36Gagliardi AR, Brouwers MC, Palda VA, Lemieux-Charles L, Grimshaw JMABSTRACT: BACKGROUND: Practice guidelines can improve health care delivery and outcomes but several issues challenge guideline adoption, including their intrinsic attributes, and whether and how they are implemented. It appears that guideline format may influence accessibility and ease of use,

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-58337916630102680822009-07-05T17:58:00.001-07:002009-07-05T17:58:30.741-07:00Heart failure in left-sided native valve infective endocarditis: characteristics, prognosis, and results of surgical treatment.

Eur J Heart Fail. 2009 Jul; 11(7): 668-75Nadji G, Rusinaru D, RÃ©madi JP, Jeu A, Sorel C, Tribouilloy CAIMS: Although congestive heart failure (CHF) represents the most common cause of death in native valve infective endocarditis (IE), recent data on the outcome of IE complicated by CHF are lacking. We aimed to analyse the characteristics and prognosis of patients with left-sided native valve IE

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-13335979744490764262009-07-03T21:27:00.001-07:002009-07-03T21:27:17.849-07:00Simultaneous Measurement of Cardiac Troponin I, B-type Natriuretic Peptide, and C-reactive Protein for the Prediction of Long-term Cardiac Outcome after Cardiac Surgery.

Anesthesiology. 2009 Jun 29; Fellahi JL, Hanouz JL, Manach YL, GuÃ© X, Monier E, Guillou L, Riou BBACKGROUND:: Simultaneous assessment of cardiac troponin I, B-type natriuretic peptide, and C-reactive protein has been found to provide unique prognostic information in acute coronary syndromes. The current study addressed the prognostic implication of a multiple-marker approach in cardiac surgery.

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-32382530889700527962009-07-03T15:27:00.001-07:002009-07-03T15:27:13.543-07:00Comparison of inflammatory biomarkers between diabetic and non-diabetic patients with unstable angina.

Arq Bras Cardiol. 2009 Apr; 92(4): 283-9Huoya Mde O, Penalva RA, Alves SR, Feitosa GS, Gadelha S, Ladeia AMBACKGROUND: Studies comparing inflammatory activity between diabetic and non-diabetic individuals with acute coronary syndrome are scarce, and none including only patients with unstable angina (UA) has been published to date. OBJECTIVE: We compared serum C-reactive protein (CRP), and

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-38489350018057204092009-07-03T01:59:00.001-07:002009-07-03T01:59:10.843-07:00Use of {beta}-Blockers in Patients with an Implantable Cardioverter Defibrillator(July/August).

Ann Pharmacother. 2009 Jun 30; Allen Lapointe NM, Stafford JA, Pappas PA, Al-Khatib SM, Anstrom KJBACKGROUND: Implantable cardioverter defibrillators (ICDs) are indicated for both primary and secondary prevention of sudden cardiac arrest. beta-Blockers are also indicated in most patients who have an indication for an ICD; however, their use in this population is not well described. Some

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-84363438296086411212009-07-02T23:08:00.001-07:002009-07-02T23:08:17.276-07:00Sertraline-Induced Rhabdomyolysis in an Elderly Patient with Dementia and Comorbidities (July/August).

Ann Pharmacother. 2009 Jun 30; Gareri P, Segura-GarcÃa C, De Fazio P, De Fazio S, De Sarro GOBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities. CASE SUMMARY: A 71-year-old woman visited a psychiatrist in September 2007 for her depressed mood. Her medical history included vascular dementia accompanied by depression, arterial

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-50381205532714353102009-07-02T15:58:00.001-07:002009-07-02T15:58:02.069-07:00[Comparison of inflammatory biomarkers between diabetic and non-diabetic patients with unstable angina.]

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-20034949675169649202009-07-02T02:28:00.001-07:002009-07-02T02:28:09.460-07:00The change in B-type natriuretic Peptide levels over time predicts significant rejection in cardiac transplant recipients.

J Heart Lung Transplant. 2009 Jul; 28(7): 704-9Kittleson MM, Skojec DV, Wittstein IS, Champion HC, Judge DP, Barouch LA, Halushka M, Hare JM, Kasper EK, Russell SDBACKGROUND: B-type natriuretic peptide (BNP) correlates with cardiac filling pressures and outcomes in patients with heart failure. In heart transplant recipients, we hypothesize that a within-individual change in BNP over time would

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-90005510022548111222009-07-01T17:54:00.000-07:002009-07-01T17:53:57.956-07:00Emergency management of decompensated peripartum cardiomyopathy.

J Emerg Trauma Shock. 2009 May; 2(2): 124-8Lata I, Gupta R, Sahu S, Singh HPeripartum cardiomyopathy (PPCM) is a rare life-threatening cardiomyopathy of unknown cause that occurs in the peripartum period in previously healthy women.[1] the symptomatic patients should receive standard therapy for heart failure, managed by a multidisciplinary team. The diagnosis of PPCM rests on the

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-35332760991099645142009-07-01T15:11:00.001-07:002009-07-01T15:11:02.997-07:00Relationship of Resting B-type Natriuretic Peptide Level to Cardiac Work and Total Physical Work Capacity in Heart Failure Patients.

J Cardiopulm Rehabil Prev. 2009 Jun 24; Norman JF, Pozehl BJ, Duncan KA, Hertzog MA, Elokda AS, Krueger SKPURPOSE: Plasma B-type natriuretic peptide (BNP) levels obtained at rest have been previously shown to be correlated with the global functional capacity measures of peak oxygen uptake (&OV0312;O2peak) and the minute ventilation/carbon dioxide (VE/&OV0312;co2) slope. The purpose of this study

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-5614409231146046552009-07-01T02:38:00.001-07:002009-07-01T02:38:35.678-07:00EANM guidelines for ventilation/perfusion scintigraphy : Part 1. Pulmonary imaging with ventilation/perfusion single photon emission tomography.

Eur J Nucl Med Mol Imaging. 2009 Jun 27; Bajc M, Neilly JB, Miniati M, Schuemichen C, Meignan M, Jonson BPulmonary embolism (PE) can only be diagnosed with imaging techniques, which in practice is performed using ventilation/perfusion scintigraphy (V/P(SCAN)) or multidetector computed tomography of the pulmonary arteries (MDCT). The epidemiology, natural history, pathophysiology and clinical

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-9383763168227130622009-06-30T16:37:00.001-07:002009-06-30T16:37:55.088-07:00Increased number of circulating progenitor cells after implantation of ventricular assist devices.

J Heart Lung Transplant. 2009 Jul; 28(7): 710-7Manginas A, Tsiavou A, Sfyrakis P, Giamouzis G, Tsourelis L, Leontiadis E, Degiannis D, Cokkinos DV, Alivizatos PABACKGROUND: Bone marrow-derived circulating progenitor cells possess tissue repair potential, improving perfusion, left ventricular remodeling, and contractility in experimental models. We quantified and investigated the kinetics of 4

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-62142207860052666152009-06-30T15:15:00.001-07:002009-06-30T15:15:12.274-07:00Potential Therapeutic Effects of Na(+)/Ca(2+) Exchanger Inhibition in Cardiac Diseases.

Curr Med Chem. 2009 Sep 1; TÃ³th A, Kiss L, VarrÃ³ A, NÃ¡nÃ¡si PPThe Na(+)/Ca(2+) exchanger (NCX) has a pivotal role in cardiac Na(+) and Ca(2+) homeostasis and is an essential pathway for Ca(2+) extrusion from cardiomyocytes. Altered NCX function may result in abnormal Ca(2+) release from the sarcoplasmic reticulum (SR) and impaired cardiac electrical activity and contractility in several

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-41319934732584744392009-06-30T06:39:00.001-07:002009-06-30T06:39:06.032-07:00Sinus rhythm restoration by catheter ablation in patients with long-lasting atrial fibrillation and congestive heart failure: impact of the left ventricular ejection fraction improvement on the implan

Europace. 2009 Jun 25; Bortone A, Boveda S, PasquiÃ© JL, Pujadas-Berthault P, Marijon E, Appetiti A, Albenque JPAims In the setting of congestive heart failure (CHF), atrial fibrillation (AF) ablation can improve clinical status and the left ventricular ejection fraction (LVEF) value. However, the impact of AF ablation on the implantable cardioverter defibrillator (ICD) indication has never been

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-60385980260069776842009-06-30T05:51:00.001-07:002009-06-30T05:51:55.363-07:00Sinus rhythm restoration by catheter ablation in patients with long-lasting atrial fibrillation and congestive heart failure: impact of the left ventricular ejection fraction improvement on the implan

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-89491647374652438982009-06-30T01:45:00.001-07:002009-06-30T01:45:49.639-07:00Sinus rhythm restoration by catheter ablation in patients with long-lasting atrial fibrillation and congestive heart failure: impact of the left ventricular ejection fraction improvement on the implan

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-39329458405942337772009-06-29T23:01:00.001-07:002009-06-29T23:01:45.705-07:00Sinus rhythm restoration by catheter ablation in patients with long-lasting atrial fibrillation and congestive heart failure: impact of the left ventricular ejection fraction improvement on the implan

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-68642703169278787352009-06-29T18:11:00.001-07:002009-06-29T18:11:26.913-07:00HYPOXIA INDUCES B-TYPE NATRIURETIC PEPTIDE RELEASE IN CELL LINES DERIVED FROM HUMAN CARDIOMYOCYTES.

Am J Physiol Heart Circ Physiol. 2009 Jun 19; Casals G, Ros J, Sionis A, Davidson MM, Morales-Ruiz M, Jimenez WB-type natriuretic peptide (BNP) is a peptide hormone of myocardial origin with significant cardioprotective properties. Patients with myocardial ischemia present with high levels of BNP in plasma and elevated expression in the myocardium. However, molecular mechanisms of BNP induction

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-45580996958488605612009-06-29T16:18:00.001-07:002009-06-29T16:18:54.302-07:00The pathophysiology of heart failure with normal ejection fraction exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwis

J Am Coll Cardiol. 2009 Jun 30; 54(1): 36-46Tan YT, Wenzelburger F, Lee E, Heatlie G, Leyva F, Patel K, Frenneaux M, Sanderson JEOBJECTIVES: The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic abnormalities, particularly involving ventricular twist and deformation (strain)

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-47537176063006904682009-06-29T15:27:00.001-07:002009-06-29T15:27:53.226-07:00Altered Hypothalamic-Pituitary-Adrenal Axis Activity in Patients with Chronic Heart Failure.

Horm Metab Res. 2009 Jun 19; Sivukhina EV, Poskrebysheva AS, Smurova IV, Dolzhikov AA, Morozov IE, Jirikowski GF, Grinevich VNeuroendocrine factors play an important role in the pathogenesis of chronic heart failure. Despite numerous clinical and experimental studies, the role of the hypothalamic-pituitary-adrenal axis and glucocorticoid hormones is not fully characterised. Here we present a

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-4050193360694401392009-06-29T01:52:00.001-07:002009-06-29T01:52:26.750-07:00The pathophysiology of heart failure with normal ejection fraction exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwis

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-3237256566691446422009-06-28T20:50:00.001-07:002009-06-28T20:50:32.633-07:00Living With Depressive Symptoms: Patients With Heart Failure.

Am J Crit Care. 2009 Jul; 18(4): 310-318Dekker RL, Peden AR, Lennie TA, Schooler MP, Moser DKBackground Patients with heart failure often experience depressive symptoms that affect health-related quality of life, morbidity, and mortality. Researchers have not described the experience of patients with heart failure living with depressive symptoms. Understanding this experience will help in

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-20954097815203561062009-06-28T18:07:00.001-07:002009-06-28T18:07:57.381-07:00The pathophysiology of heart failure with normal ejection fraction exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwis

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-75775323205128358392009-06-28T15:48:00.001-07:002009-06-28T15:48:54.332-07:00Revised Cardiac Risk Index (Lee) and Perioperative Cardiac Events as Predictors of Long-term Mortality in Patients Undergoing Endovascular Abdominal Aortic Aneurysm Repair.

J Cardiothorac Vasc Anesth. 2009 Jun 24; Archan S, Roscher CR, Fairman RM, Fleisher LAOBJECTIVE: To determine if the Revised Cardiac Risk Index (Lee) is useful for stratification of patients by risk of both perioperative cardiac morbidity and long-term all-cause mortality in the setting of endovascular repair of abdominal aortic aneurysms. DESIGN: This study was designed as a retrospective

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-42190952601446691622009-06-28T02:19:00.001-07:002009-06-28T02:19:07.921-07:00The pathophysiology of heart failure with normal ejection fraction exercise echocardiography reveals complex abnormalities of both systolic and diastolic ventricular function involving torsion, untwis

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-21811342300181081182009-06-27T22:03:00.001-07:002009-06-27T22:03:38.348-07:00Gastrointestinal bleeding in high risk survivors of myocardial infarction: the VALIANT Trial.

Eur Heart J. 2009 Jun 25; Moukarbel GV, Signorovitch JE, Pfeffer MA, McMurray JJ, White HD, Maggioni AP, Velazquez EJ, Califf RM, Scheiman JM, Solomon SDAims The risk of gastrointestinal (GI) bleeding limits the use of antiplatelet and anticoagulant drugs. Risk factors for GI bleeding in post- myocardial infarction (MI) patients have not been well defined. We sought to identify risk factors for

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-95592142093222832009-06-27T21:41:00.001-07:002009-06-27T21:41:47.414-07:00Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility. Implications for Ruboxistaurin As a Novel Therapeutic Approach.

Circ Res. 2009 Jun 25; Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JDProtein kinase (PK)Calpha, PKCbeta, and PKCgamma comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness. Indeed, mice lacking the gene for PKCalpha show enhanced cardiac contractility and reduced susceptibility to heart failure.

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-72284299779168079312009-06-27T17:27:00.001-07:002009-06-27T17:27:56.637-07:00Proof of concept hemodynamic response to long-term partial ventricular support with the synergy pocket micro-pump.

J Am Coll Cardiol. 2009 Jun 30; 54(1): 79-86Meyns B, Klotz S, Simon A, Droogne W, Rega F, Griffith B, Dowling R, Zucker MJ, Burkhoff DOBJECTIVES: The purpose of this study was to test the hemodynamic effects of partial ventricular support in patients with advanced heart failure. BACKGROUND: The use of current left ventricular assist devices (VADs) that provide full circulatory support is

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-85013521713271418632009-06-27T17:16:00.001-07:002009-06-27T17:16:14.733-07:00Milrinone inhibits hypoxia or hydrogen dioxide-induced persistent sodium current in ventricular myocytes.

Eur J Pharmacol. 2009 Jun 20; Zheng J, Ma J, Zhang P, Hu L, Fan X, Tang QMuch evidence indicates that increased persistent sodium current (I(Na.P)) is associated with cellular calcium overload and I(Na.P) is considered to be a potential target for therapeutic intervention in ischaemia and heart failure. By inhibiting type III phosphodiesterase, milrinone increases intracellular cyclic adenosine

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-49574524035874846592009-06-26T18:23:00.001-07:002009-06-26T18:23:19.321-07:00Short-term mortality and complications in ST elevation myocardial infarction--the Heart Hospital experience.

J Indian Med Assoc. 2008 Oct; 106(10): 650-4Achari V, Prakash S, Sinha AK, Thakur AKThe mortality rate of acute myocardial infarction has declined considerably in the past three decades. In view of paucity of literature from different centres from India on this issue, the present study was undertaken to determine the in-hospital mortality with acute ST segment elevation myocardial infarction

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-64500629051672895772009-06-26T15:37:00.001-07:002009-06-26T15:37:31.899-07:00Routine early angioplasty after fibrinolysis for acute myocardial infarction.

N Engl J Med. 2009 Jun 25; 360(26): 2705-18Cantor WJ, Fitchett D, Borgundvaag B, Ducas J, Heffernan M, Cohen EA, Morrison LJ, Langer A, Dzavik V, Mehta SR, Lazzam C, Schwartz B, Casanova A, Goodman SG, BACKGROUND: Patients with a myocardial infarction with ST-segment elevation who present to hospitals that do not have the capability of performing percutaneous coronary intervention (PCI) often

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-52496004046019235322009-06-26T06:27:00.001-07:002009-06-26T06:27:58.976-07:00Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.

Proc Natl Acad Sci U S A. 2009 Jun 23; Harzheim D, Movassagh M, Foo RS, Ritter O, Tashfeen A, Conway SJ, Bootman MD, Roderick HLCardiac hypertrophy is a growth response of the heart to increased hemodynamic demand or damage. Accompanying this heart enlargement is a remodeling of Ca(2+) signaling. Due to its fundamental role in controlling cardiomyocyte contraction during every heartbeat,

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-15599914878378929862009-06-26T02:14:00.001-07:002009-06-26T02:14:22.439-07:00[Innovations in the epidemiology, natural history, diagnosis and treatment of sleep apnea-hypopnea syndrome]

Arch Bronconeumol. 2009; 45 Suppl 1: 3-10HernÃ¡ndez C, DurÃ¡n-Cantolla J, Lloberes P, GonzÃ¡lez MThe following review summarises the most important articles published on sleep apnea-hypopnea syndrome (SAHS) during the current year. The analysis of the many factors implicated in the risk of cardiovascular diseases associated with SAHS is currently of great interest to the scientific community.

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-70932502092207071982009-06-26T01:17:00.001-07:002009-06-26T01:17:32.892-07:00Thyroid Hormone Antagonists: Potential Medical Applications and Structure Activity Relationships.

Curr Med Chem. 2009 Sep 1; Malm J, FÃ¤rnegÃ¢rdh M, Grover GJ, Ladenson PWThyroid hormone receptors (TRs) exert profound effects on development, metabolism, and multiple specific organ functions. Principally by regulating crucial genes in a variety of tissues, the thyroid hormones, 3,5,3'-triiodo-L-thyronine (L-T(3), 1) and 3,5,3',5'-tetraiodo-L-thyronine (L-T(4), 2), influence basal

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-76875656663353370832009-06-25T18:00:00.001-07:002009-06-25T18:00:13.041-07:00The Association Between Emergency Department Crowding and Adverse Cardiovascular Outcomes in Patients with Chest Pain.

Acad Emerg Med. 2009 Jun 22; Pines JM, Pollack CV, Diercks DB, Chang AM, Shofer FS, Hollander JEObjectives: While emergency department (ED) crowding is a worldwide problem, few studies have demonstrated associations between crowding and outcomes. The authors examined whether ED crowding was associated with adverse cardiovascular outcomes in patients with chest pain syndromes (chest pain or

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-41742343868144719532009-06-25T14:57:00.001-07:002009-06-25T14:57:40.998-07:00Reduced L-arginine transport contributes to the pathogenesis of myocardial ischemia-reperfusion injury.

J Cell Biochem. 2009 Jun 18; Venardos KM, Zatta AJ, Marshall T, Ritchie R, Kaye DMMyocardial injury due to ischemia-reperfusion (I-R) damage remains a major clinical challenge. Its pathogenesis is complex including endothelial dysfunction and heightened oxidative stress although the key driving mechanism remains uncertain. In this study we tested the hypothesis that the I-R process induces a

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-10951669641059129502009-06-25T05:41:00.001-07:002009-06-25T05:41:21.264-07:00Cardiac rehabilitation and artificial heart devices.

J Artif Organs. 2009; 12(2): 90-7Ueno A, Tomizawa YRecently, cardiac rehabilitation has gained popularity in Japan because beneficial effects on patients' prognosis have been reported. Another reason is that cardiac rehabilitation has been covered by health insurance since 1988 in Japan. Currently, cardiac rehabilitation is covered for the diseases of angina pectoris, acute myocardial infarction

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-65064559447395989502009-06-25T01:07:00.001-07:002009-06-25T01:07:14.037-07:00Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure.

Peptides. 2009 Jun 18; Del Ry S, Cabiati M, Lionetti V, Simioniuc A, Caselli C, Prescimone T, Emdin M, Giannessi DHigh-frequency pacing of the left ventricle (LV) free wall causes a dyssynchronous pattern of contraction that leads to progressive heart failure (HF) with pronounced differences in regional contractility. Aim of this study was to evaluate possible changes in brain natriuretic

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-66167329134347412702009-06-24T21:44:00.001-07:002009-06-24T21:44:24.320-07:00Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide.

Proc Natl Acad Sci U S A. 2009 Jun 18; Pan S, Chen HH, Dickey DM, Boerrigter G, Lee C, Kleppe LS, Hall JL, Lerman A, Redfield MM, Potter LR, Burnett JC, Simari RDAlternative RNA splicing may provide unique opportunities to identify drug targets and therapeutics. We identified an alternative spliced transcript for B-type natriuretic peptide (BNP) resulting from intronic retention. This transcript

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-81396362208864673972009-06-24T18:06:00.001-07:002009-06-24T18:06:43.221-07:00National trends in rates of death and hospital admissions related to acute myocardial infarction, heart failure and stroke, 1994-2004.

CMAJ. 2009 Jun 23; 180(13): E118-E125Tu JV, Nardi L, Fang J, Liu J, Khalid L, Johansen H, BACKGROUND: Rates of death from cardiovascular and cerebrovascular diseases have been steadily declining over the past few decades. Whether such declines are occurring to a similar degree for common disorders such as acute myocardial infarction, heart failure and stroke is uncertain. We examined recent

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-75578841852339164312009-06-24T16:14:00.001-07:002009-06-24T16:14:54.260-07:00A novel approach for endocardial resynchronization therapy: initial experience with transapical implantation of the left ventricular lead.

Heart Surg Forum. 2009 Jun; 12(3): E137-40Kassai I, Mihalcz A, Foldesi C, Kardos A, Szili-Torok TBackground: Coronary sinus lead placement for transvenous left ventricular (LV) pacing in cardiac resynchronization therapy (CRT) has a significant failure rate at implant and a considerable dislocation rate during follow-up. For these patients epicardial pacing lead implantation is the most

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-7071682232415420502009-06-24T15:53:00.001-07:002009-06-24T15:53:34.738-07:00Patients with Anorectal Malformation and Hirschsprung's Disease.

Eur J Pediatr Surg. 2009 Jun 22; Raboei EHBACKGROUND: Dysganglionosis and aganglionosis have been frequently described in biopsies of the distal bowel in patients with anorectal malformation (ARM). They are interpreted as a developmental disorder of the anorectum. The true association of total colonic aganglionosis and anorectal malformation has not been reported before. The aim of this study

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-21743922148782474532009-06-24T04:34:00.001-07:002009-06-24T04:34:38.892-07:00Chronic Renal Insufficiency Cohort (CRIC) Study: Baseline Characteristics and Associations with Kidney Function.

Clin J Am Soc Nephrol. 2009 Jun 18; Lash JP, Go AS, Appel LJ, He J, Ojo A, Rahman M, Townsend RR, Xie D, Cifelli D, Cohan J, Fink JC, Fischer MJ, Gadegbeku C, Hamm LL, Kusek JW, Landis JR, Narva A, Robinson N, Teal V, Feldman HI, BACKGROUND AND OBJECTIVES: The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for the progression of chronic kidney disease (

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-4839802955760165552009-06-23T21:35:00.001-07:002009-06-23T21:35:13.797-07:00A Novel Aging Phenotype of Slow Gait, Impaired Executive Function, and Depressive Symptoms: Relationship to Blood Pressure and Other Cardiovascular Risks.

J Gerontol A Biol Sci Med Sci. 2009 Jun 17; Hajjar I, Yang F, Sorond F, Jones RN, Milberg W, Cupples LA, Lipsitz LABACKGROUND: Our objectives were to investigate the existence of a group of nondemented elderly individuals who simultaneously have impairments in cognition, mobility, and mood, and to examine the association between being a member of this group and elevated blood pressure and other

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-81094678231991623892009-06-23T18:46:00.001-07:002009-06-23T18:46:24.294-07:00Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'

Eur Heart J. 2009 Jun 17; Kirchhof P, Bax J, Blomstrom-Lundquist C, Calkins H, John Camm A, Cappato R, Cosio F, Crijns H, Diener HC, Goette A, Israel CW, Kuck KH, Lip GY, Nattel S, Page RL, Ravens U, Schotten U, Steinbeck G, Vardas P, Waldo A, Wegscheider K, Willems S, Breithardt GAtrial fibrillation (AF) causes important mortality and morbidity on a population-level. So far, we do not have the

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-83627875866444377202009-06-20T17:22:00.001-07:002009-06-20T17:22:05.383-07:00Oral Nicorandil to Reduce Cardiac Death After Coronary Revascularization in Hemodialysis Patients: A Randomized Trial.

Am J Kidney Dis. 2009 Jun 16; Nishimura M, Tokoro T, Nishida M, Hashimoto T, Kobayashi H, Imai R, Yamazaki S, Okino K, Iwamoto N, Takahashi H, Ono TBACKGROUND: Survival after invasive coronary revascularization is worse in patients with chronic kidney disease than in patients without chronic kidney disease. We examined whether oral administration of nicorandil, a hybrid nitrate and adenosine

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-31053465618396841292009-06-19T15:25:00.001-07:002009-06-19T15:25:16.120-07:00Importance of practical simulation training for troubleshooting the heart-lung machine.

J Artif Organs. 2009; 12(2): 67-72Kenmoku KThe artificial heart-lung system is a device that replaces the patient's respiratory and circulatory function during surgery on the heart and great vessels. Users must operate the system by properly recognizing and appropriately evaluating various types of information and by providing feedback to the machine; inappropriate interaction between humans and

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-31904333041415725992009-06-19T14:03:00.001-07:002009-06-19T14:03:57.821-07:00The Effect of July Admission in the Process of Care of Patients with Acute Cardiovascular Conditions.

South Med J. 2009 May 7; Garcia S, Canoniero M, Young LBACKGROUND:: Little information is available to measure the impact of new trainees in the process of care and outcomes of patients with acute cardiovascular conditions. The objective of this investigation is to assess whether physicians' experience has an impact on the quality of health care delivery. METHODS:: Two cohorts of hospitalized

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-2536383861325172652009-06-19T07:31:00.001-07:002009-06-19T07:31:44.792-07:00Dual ACE-inhibition and AT1 receptor antagonism improves ventricular lusitropy without affecting cardiac fibrosis in the congenic mRen2.Lewis rat.

Ther Adv Cardiovasc Dis. 2009 Jun 16; Jessup JA, Westwood BM, Chappell MC, Groban LBACKGROUND: Hypertension and left ventricular (LV) hypertrophy often precede diastolic dysfunction and are risk factors for diastolic heart failure. Although pharmacologic inhibition of the renin-angiotensin system (RAS) improves diastolic function and functional capacity in hypertensive patients with LV

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-30961853532935950702009-06-19T02:49:00.001-07:002009-06-19T02:49:58.190-07:00Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: an in vitro study.

Eur J Clin Invest. 2009 Jun 15; Huang WP, Yin WH, Chen JW, Jen HL, Young MS, Lin SJEur J Clin Invest 2009Abstract Background Inflammation is implicated in chronic heart failure (CHF). In this study, the potential inhibitory effect of peroxisome proliferator-activated receptor-alpha (PPARalpha) activator fenofibrate on monocyte adhesion in CHF patients was investigated in vitro. Materials and

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-85868526136167910592009-06-18T22:13:00.001-07:002009-06-18T22:13:54.464-07:00Dying, death and bereavement: a qualitative study of the views of carers of people with heart failure in the UK.

BMC Palliat Care. 2009 Jun 16; 8(1): 6Small N, Barnes S, Gott M, Payne S, Parker C, Seamark D, Gariballa SABSTRACT: BACKGROUND: This paper explores carers' views of dying, death and bereavement for family members who had recently died with heart failure adding to a growing literature on end of life experiences for people with conditions other than cancer. METHOD: Twenty interviews were conducted

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-48320832813581798662009-06-18T15:21:00.001-07:002009-06-18T15:21:08.231-07:00Levosimendan in perioperative and critical care patients.

Curr Opin Anaesthesiol. 2009 Jun 4; SalmenperÃ¤ M, Eriksson HPURPOSE OF REVIEW: To present recent experiences and studies on the pharmacologic profile of levosimendan in the context of surgery, anesthesia and critical care. Special emphasis is on the studies that could support the use of or create novel indications for levosimendan in these patients. RECENT FINDINGS: Several controlled studies

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-33718345649923107892009-06-18T13:57:00.001-07:002009-06-18T13:57:07.131-07:00Echocardiographic evaluation of diastolic function in asymptomatic type 2 diabetes.

JNMA J Nepal Med Assoc. 2009 Jan-Mar; 48(173): 20-3Shrestha NR, Sharma SK, Karki P, Shrestha NK, Acharya PINTRODUCTION: Diabetes mellitus is an established risk factor for congestive cardiac failure in which the diastolic function is impaired earlier than the systolic function and majority of these patients maybe asymptomatic without signs of overt heart failure. METHODS: A cross sectional

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-62921767086717131252009-06-18T07:25:00.001-07:002009-06-18T07:25:53.783-07:00Mechanism of Diastolic Stiffening of the Failing Myocardium and Its Prevention by Angiotensin Receptor and Calcium Channel Blockers.

J Cardiovasc Pharmacol. 2009 Jun 12; Cheng XW, Okumura K, Kuzuya M, Jin Z, Nagata K, Obata K, Inoue A, Hirashiki A, Takeshita K, Unno K, Harada K, Shi GP, Yokota M, Murohara TOBJECTIVE:: To investigate the mechanism responsible for the increased cardiac stiffness associated with hypertensive heart failure in Dahl salt-sensitive (DS) rats and the effects of treatment with the combination of a

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-47868366503522446942009-06-18T02:44:00.001-07:002009-06-18T02:44:16.962-07:00Cardiovascular Evaluation and Management of Severely Obese Patients Undergoing Surgery. A Science Advisory From the American Heart Association.

Circulation. 2009 Jun 15; Poirier P, Alpert MA, Fleisher LA, Thompson PD, Sugerman HJ, Burke LE, Marceau P, Franklin BA, Abstract-Obesity is associated with comorbidities that may lead to disability and death. During the past 20 years, the number of individuals with a body mass index >30, 40, and 50 kg/m(2), respectively, has doubled, quadrupled, and quintupled in the United States. The risk of

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-14802644090678394122009-06-17T23:08:00.001-07:002009-06-17T23:08:23.208-07:00Adverse events after outpatient colonoscopy in the medicare population.

Ann Intern Med. 2009 Jun 16; 150(12): 849-57, W152Warren JL, Klabunde CN, Mariotto AB, Meekins A, Topor M, Brown ML, Ransohoff DFBACKGROUND: Although use of colonoscopy has increased substantially among elderly Medicare beneficiaries, no one has described colonoscopy-related adverse events in a representative sample of Medicare patients. OBJECTIVE: To determine risk for adverse events after

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-67096220857687807232009-06-17T15:46:00.001-07:002009-06-17T15:46:03.119-07:00IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure.

Exp Mol Pathol. 2009 Jun 12; Feng W, Li W, Liu W, Wang F, Li Y, Yan WOBJECTIVE: This study was designed to investigate whether IL-17 can regulate the expression of the MMP/TIMP system, the OPG/RANK/RANKL system, or type-I and type-III collagen fibers in a rat model of isoproterenol-induced heart failure (HF). We also investigated the effect of IL-17 on myocardial fibrosis in this model. METHODS:

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-88408204994539385862009-06-17T13:45:00.001-07:002009-06-17T13:45:26.683-07:00Sarcolemmal fatty acid uptake vs. mitochondrial beta-oxidation as target to regress cardiac insulin resistance.

Appl Physiol Nutr Metab. 2009 Jun; 34(3): 473-80Luiken JJCardiomyopathy and heart failure are frequent comorbid conditions in type-2 diabetic patients. However, it has become increasingly evident that insulin resistance, type-2 diabetes, and cardiomyopathy are not independent variables, and are linked through changes in metabolism. Specifically, elevated intracellular levels of long-chain fatty

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-91864469917312295362009-06-17T07:02:00.001-07:002009-06-17T07:02:43.617-07:00Parasympathetic Effects on Cardiac Electrophysiology during Exercise and Recovery in Patients with Left Ventricular Dysfunction.

Am J Physiol Heart Circ Physiol. 2009 Jun 12; Chicos AB, Kannankeril PJ, Kadish AH, Goldberger JJDepressed parasympathetic activity has been proposed to be associated with an increased risk of sudden death. Parasympathetic effects (PE) on cardiac electrophysiology during exercise and recovery have not been studied in patients with left ventricular dysfunction. We performed non-invasive

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-87652864543325967312009-06-17T05:08:00.001-07:002009-06-17T05:08:18.726-07:00Acute modulation of myocardial function by angiotensin 1-7.

Peptides. 2009 Jun 11; Castro-Chaves P, Pintalhao M, Fontes-Carvalho R, Cerqueira R, Leite-Moreira AFAngiotensin 1-7 is a bioactive heptapeptide of the renin-angiotensin system. Its cardiovascular actions have recently acquired growing relevance, mainly due to its counter-regulatory actions in the angiotensin cascade. The aim of the present study was to evaluate the actions of angiotensin 1-7 on

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-53892786713367068832009-06-16T16:06:00.001-07:002009-06-16T16:06:52.609-07:00CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation.

Nature. 2009 Jun 14; Zanoni I, Ostuni R, Capuano G, Collini M, Caccia M, Ronchi AE, Rocchetti M, Mingozzi F, Foti M, Chirico G, Costa B, Zaza A, Ricciardi-Castagnoli P, Granucci FToll-like receptors (TLRs) are the best characterized pattern recognition receptors. Individual TLRs recruit diverse combinations of adaptor proteins, triggering signal transduction pathways and leading to the

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-11786526350025226112009-06-16T15:27:00.001-07:002009-06-16T15:27:13.091-07:00Induced overexpression of Na+/Ca2+ exchanger transgene: Altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents and action potential duration.

Am J Physiol Heart Circ Physiol. 2009 Jun 12; Wang J, Chan TO, Zhang XQ, Gao E, Song J, Koch WJ, Feldman AM, Cheung JYWe have produced mice in which expression of the rat cardiac Na(+)/Ca(2+) exchanger (NCX1) transgene was switched on when doxycycline was removed from the feed at 5 weeks. At 8 to 10 weeks, NCX1 expression in induced (Ind) mouse hearts was 2.5-fold higher but protein levels of

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-88112513908400570582009-06-16T13:55:00.001-07:002009-06-16T13:55:19.726-07:00PleurX catheter for the management of refractory pleural effusions in congestive heart failure.

Tex Heart Inst J. 2009; 36(1): 38-43Herlihy JP, Loyalka P, Gnananandh J, Gregoric ID, Dahlberg CG, Kar B, Delgado RMPleural effusions that are caused by congestive heart failure and refractory to medical management are rare, and the options for treating them are few and sometimes ineffective. We report here our experience, over a 2-year period, with a novel device, the Denver Biomedical PleurX

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-67948814707438700622009-06-16T01:42:00.001-07:002009-06-16T01:42:39.899-07:00Diabetic cardiomyopathy--a distinct disease?

Best Pract Res Clin Endocrinol Metab. 2009 Jun; 23(3): 347-60Khavandi K, Khavandi A, Asghar O, Greenstein A, Withers S, Heagerty AM, Malik RADiabetic individuals have a significantly increased likelihood of developing cardiovascular disease. Whilst part of this association is explained by the presence of concomitant risk factors, large epidemiological studies have consistently reported diabetes

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-25773788792564217842009-06-15T22:54:00.001-07:002009-06-15T22:54:27.632-07:00G Protein-Coupled Receptor Kinase 2 Expression and Activity Are Associated With Blood Pressure in Black Americans.

Hypertension. 2009 Jun 1; Cohn HI, Xi Y, Pesant S, Harris DM, Hyslop T, Falkner B, Eckhart ADHypertension occurs with higher prevalence and morbidity in black Americans compared with other groups. Alterations in the signal transduction pathways of 7-transmembrane spanning receptors are found in hypertensive patients. G protein-coupled receptor kinases (GRKs) play an important role in regulating

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-10450269871592893812009-06-15T14:33:00.001-07:002009-06-15T14:33:06.609-07:00Remote Ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold blood cardioplegia:a randomised controlled trial.

Heart. 2009 Jun 8; Venugopal V, Hausenloy DJ, Ludman A, Di Salvo C, Kolvekar S, Yap J, Lawrence D, Bognolo G, Yellon DMOBJECTIVE: Remote ischaemic preconditioning (RIPC) induced by brief limb ischaemia reduces myocardial injury in coronary artery bypass (CABG) surgery patients receiving predominantly cross-clamp fibrillation for myocardial protection. However, cold-blood cardioplegia is the more

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-38660468630736942832009-06-15T13:49:00.001-07:002009-06-15T13:49:24.312-07:00Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases.

J Pharmacol Exp Ther. 2009 Jun 9; Javadov S, Karmazyn M, Escobales NIn addition to their central role in ATP synthesis, mitochondria play a critical role in cell death. Oxidative stress accompanied by calcium overload, ATP depletion and elevated phosphate levels induces mitochondrial permeability transition (MPT) with formation of non-specific MPT pores (MPTP) in the inner mitochondrial membrane

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-55765919674786764482009-06-15T12:39:00.001-07:002009-06-15T12:39:45.046-07:00Utility of immunofluorescence and electron microscopy in endomyocardial biopsies from patients with unexplained heart failure.

Cardiovasc Pathol. 2009 Jun 5; She RC, Hammond EHBACKGROUND: With our increasing understanding of inflammatory heart disease, the relevance of Dallas criteria has come into question. Immunofluorescence (IF) and electron microscopy (EM) can potentially identify immune reactants and ultrastructural changes not visible by light microscopy (LM), particularly in cases not meeting Dallas criteria.

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.comtag:blogger.com,1999:blog-2803382791321202921.post-58098138269550635082009-06-14T18:36:00.001-07:002009-06-14T18:36:27.169-07:00Diabetic cardiomyopathy - a distinct disease?

Slashttp://www.blogger.com/profile/01432494485961524278noreply@blogger.com